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Disturbed shear stress diminishes the expression of protective genes, such as Aff3ir-ORF2, which possesses anti-inflammatory and anti-atherosclerotic properties

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however, further validation could be achieved via (i) targeted perturbation of candidate nodes (e.g

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Pinto A, Daly A, Evans S, Almeida MF, Assoun M, Belanger-Quintana A, et al

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Biochem Pharmacol 2008

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