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B12 low levels cause defective production of choline and choline containing phospholipids, causes demyelination, followed by axonal degeneration and ultimately axonal death

Driving AMPA receptors into synapses by LTP and CaMKII: requirement for GluR1 and PDZ domain interaction

As with other substance use disorders, both genetic (such as mutations in the opioid receptor gene (10)) and environmental factors (such as exposure to trauma), contribute to the risk of developing opioid use disorder.(11) Ready access to prescription opioid, heroin, and fentanyl have all contributed to the current opioid epidemic

The myelin sheath comprises lipids, notably phosphoglycerides, sphingolipids, neutral lipids, and proteins, including myelin basic protein (MBP) and proteolipid protein (PLP) [70]