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10.1016/j.molcel.2017.12.028 Mol Cell

However, several histological abnormalities were found in these mice, abnormalities that spanned several tissues and included chronic inflammation and hyperplasia of the gastric epithelium, calcification in the brain, testicular atrophy, loss of cytoplasmic granules in the striated duct cells of the salivary gland, and thinning of compact bone

Notably, MCP-1, also known as chemokine ligand 2 (CCL2), plays a pivotal role in promoting BBB instability by facilitating the recruitment of monocytes/Ms into CNS compartment and contributing to the reorganization of TJ and the actin cytoskeleton (Stamatovic et al., 2003)

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Pain Control: This IV uses a titrated dose of procaine, an anesthetic that breaks down into anti-inflammatory compounds, and has the effect of reducing pain due to inflammatory conditions