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In addition, ERK2 KD greatly inhibited the binding of SIRT7 to UBR5 and the EGF-facilitated SIRT7 ubiquitination

Carbone S, Lavie CJ, Elagizi A, Arena R, Ventura HO (2022) The impact of obesity in heart failure

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Aged animals typically show significant deficits on these tasks due to progressive synaptic loss and reduced neuroplasticity

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