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Additionally, downregulation of ER-plasma membrane tethering proteins and upregulation of ER stress proteins (specific targets not provided) suggested the involvement of unfolded protein response (UPR) activation in lipid accumulation

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Corsini EM, Wang Q, Tran HT, Mitchell KG, Antonoff MB, Hofstetter WL, Mehran RJ, Rice DC , Roth JA, Swisher SG, Vaporciyan AA, Walsh GL, Reuben A, Vasquez ME, Bernatchez C, Wang J, Cascone T, Zhang J, Heymach JV, Gibbons DL, Haymaker CL, Sepesi B

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Ames mice maintained a nearly 1:1 (0.94) ratio of SAM to SAH on MET restriction, whereas in wild-type mice, this ratio was 1.49 (Figure 2)