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This study has significant limitations

Required documentation includes recent testosterone lab results, symptom questionnaires, physical examination findings, and treatment rationale

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Anti-diabetic medications that are now on the market are expensive and have several negative effects, including cardiac, hepatic, and renal failure in diabetic patients

Caffeine can also inhibit phosphodiesterase and suppresses the negative effects of adenosine on noradrenaline release, thus can induce fat oxidation (Reference Dulloo, Seydoux and Girardier7)

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