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acetyl-CoA is the primary substrate for the Krebs cycle, once it is de-acetylated, it must be re-charged with an acetyl-group in order for the Krebs cycle to keep working

Carnitine plays an essential role in fat metabolism as it basically functions as a transporter for fatty acids within the body

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Cardiac failure is characterized by myocardial infarction (MI), ventricular systolic dysfunction, and reduced cardiac muscle contraction along with the flow of blood (Roan et al., 1982)