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The evolving role of the NAD + /nicotinamide metabolome in skin homeostasis, cellular bioenergetics, and aging

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e , The distances between catalytic residues Sec46 and Trp136 were recorded every 4.8 ps throughout MD simulations of GPX4 WT (PDB: 6HN3), GPX4 K48A , GPX4 K48L , GPX4 K48E , GPX4 K48Q , and GPX4 K48R

Intrinsic aging is characterized by epidermal thinning, dryness, fine lines, and reduced elasticity over time, whereas extrinsic aging manifests as epidermal thickening, deep wrinkles, skin laxity, roughness, and pigmentation, particularly in sun-exposed areas, such as the face, neck, and hands