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Recent studies and meta-analysis report a higher occurrence of RA in patients with moderate to severe periodontitis compared to controls, and a higher prevalence of periodontitis and periodontal destruction in RA subjects compared to non-RA subjects 6,7,8,9,10,11,12

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However, even after correcting serum vitamin B 12 and its metabolite levels, or haematological abnormalities, the ability to reverse cognitive impairment (dementia) and neurological disorders is not promising.50 51 52 The longer the time the neurological disorder or cognitive impairment presents before treatment, the less likely it can be reversed

Eldarov C, Gamisonia A, Chagovets V, et al

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Tang S-C, Yeh S-J, Tsai L-K, Hu C-J, Lien L-M, Peng G-S, et al