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With early diagnosis and lifestyle changes, we can manage this condition and prevent serious complications

The released mtDNA can activate cGASSTING signaling, creating a self-reinforcing loop where inflammation further impairs mitochondrial quality control, promotes additional mtDNA release, and accelerates neuronal degeneration

Involvement of PI3K/PKG/ERK1/2 signaling pathways in cortical neurons to trigger protection by cotreatment of acetyl-L-carnitine and alpha-lipoic acid against HNE-mediated oxidative stress and neurotoxicity: implications for Alzheimer's disease

I wonder how our bodies decide what is excess and what is not

doi: 10.1016/j.clnu.2025.06.006 12 NewmanJCVerdinE

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