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Recently, Okuda and colleagues demonstrated that intra-striatal injection of mouse syn pre-formed fibrils (PFF) in BAC- SNCA A53T/ induces a more severe syn pathology than in mice expressing wild-type human syn, as well as more severe than the intra-striatal injection of human syn PFF

However, substitutions can also occur at positions 5, 7, 3, 4, and 5

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Extracellular marker assays Circulating cell free mitochondria DNA (ccf-mtDNA) DNA extraction was performed using QiaAMP DNA mini kit (Qiagen) from cell culture supernatants