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however, conflicting findings have been documented
Abbreviations LDs: Lipid droplets ER: Endoplasmic reticulum TAGs: Triacylglycerols DAGs: Diacylglycerols SEs: Sterol esters BBB: BloodBrain Barrier DGAT: Diacylglycerol acyltransferase GPAT: Glycerol 3 phosphate acyltransferase AGPAT: Acylglycerol 3 phosphate PAP: Phosphatidate phosphate FATP: Fatty acid transport protein MGAT2: Monoacylglycerol acyltransferase SCD1: Stearoyl-CoA Desaturase 1 nLDs: Nuclear lipid droplets PLIN5: Perilipin 5 PLIN1: Perilipn 1 PLIN2: Perilipn 2 PLIN3: Perilipn 3 PKA: Protein kinase A PKB: Protein kinase B SIRT1: Sirtuin1 CRABP1: Cellular retinoic acid-binding protein 1 ATRA: All-transretinoic Acid TLR: Toll-like receptor EGF: Epidermal growth factor RIG-I: Retinoic acid-inducible gene-I PRR: Patter recognition receptor IFNs: Interferons NDRG1: N-myc downstream-regulated gene 1 USP15: Ubiquitin Specific Peptidase 15 PGC-1: Peroxisome proliferator-activated receptor gamma 1 AMPK: AMP-activated protein kinase LDMC: Lipid droplets mitochondrial coupling MFN2: Mitofusin2 CMA: Chaperon-mediated autophagy LDAF1: Lipid droplet assembly factor 1 MGAT2: Monoacylglycerol acetyltransferase 2 FATP: Fatty acid transporter protein SCD1: Stearoyl COA desaturase 1 IGTP: Interferon-gamma inducible guanine IFI47: Interferon-gamma inducible protein IIGP1: Interferon-inducible guanine triphosphatase 1 TGTP1: T cell-specific GTPase1 cPLA2: Phospholipase A2 SREBP: Sterol regulatory binding element protein SKI-1/S1P: Subtilisin kexin isozyme-1/site 1 protease PI3K: Phosphoinositide 3-kinase AUP1: Ancient ubiquitous protein 1 NS4A: Nonstructural protein 4A NS4B: Nonstructural protein 4B NS5A: Nonstructural protein 5A NS3: Nonstructural protein 3 DENV: Dengue virus JEV: Japanese encephalitis virus ADRP: Adipose differentiation-related protein PAR: Peroxisome proliferator-activated receptor gamma HSL: Hormone-sensitive lipase ATGL: Adipose triglyceride lipase ZIKAV: Zika virus HCV: Hepatitis C virus MAP1LC3: Microtube-associated protein 1 light chain 3 AD: Alzheimer's disease PD: Parkinson's disease ALS: Amyotrophic lateral sclerosis MCT: Monocarboxylate transporter JNK: C jun N terminal kinase Syn: Alpha-synuclein CNS: Central nervous system ROS: Reactive oxygen species MRP: Multidrug resistance-associated protein ABC: ATP binding cassette P-gp: P glycoprotein DMPC: Dimyristoyl-sn-glycerol-3-phosphocholine DMPG: 1,2-Dimyristoyl-sn-glycerol-3-phosphoglycerol DSPE: 1,2-Distearoyl-sn-glycerol-3-phosphoethanolamine PEG: Polyethylene glycol FIT: Fat storage-inducing transmembrane protein References Acevedo N, Waggoner J, Rodriguez M et al (2017) Zika virus, chikungunya virus, and dengue virus in cerebrospinal fluid from adults with neurological manifestations, Guayaquil, Ecuador
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Acta Pharmacol Sin 23:412422 Sikiric P, Seiwerth S, Brcic L et al (2010) Revised Roberts cytoprotection and adaptive cytoprotection and stable gastric pentadecapeptide BPC 157
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