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Data from the Minnesota Green Tea Trial showed a 6.7% incidence of ALT elevation in postmenopausal women consuming 843 mg/day EGCG, with polymorphisms in the COMT and UGT1A4 genes contributing to interindividual variability in toxicity (245)

Niacinamide does not cause the dramatic flush of niacin, so titration to mitigate flushing is usually not necessary

Circulating carotenoids and risk of breast cancer: Pooled analysis of eight prospective studies

Trial data describe pharmaceutical-grade material under monitoring

Activation of PPAR not only ameliorates the metabolic syndrome but also exhibits anti-inflammatory effects [46]

This work was supported by EU grant QLG 1-CT-1999-00739 and Wilhelm Sander-Stiftung grant 2002.045.1