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Likewise, acriflavine, an antibacterial drug that was clinically used before penicillin, was noticed to directly bind to the HIF-1 and HIF-2 PAS-B subdomain and prevents them from interacting with HIF-1, preventing the transcription of genes controlled by HIF and impairing the development and vascularization of the tumor [99,100,101]

In addition, carbonic anhydrase generates additional H + by catalyzing the excessive CO 2 hydration produced by the pentose phosphate pathway in tumor cells, which also contributes to the formation of acidic TME (50)

The new active improves glutathione levels, which is known as a strong antioxidant in the body

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Battle SL, Puiu D, Verlouw J, Broer L, Boerwinkle E, Taylor KD, Rotter JI, Rich SS, Grove ML, Pankratz N, et al

After multiple exams and misdiagnoses, she was told she had MS and was put on immune suppression drugs