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The clarification of the mechanism of action and the evaluation of long term safety and efficacy also at heart level can add important pre-clinical data to plan clinical trials in DMD patients (Table 1)

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Despite its growing popularity, the clinical efficacy and safety of BPC-157 remain unproven, raising significant ethical and legal concerns

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However, in primary colon cancer, methylated BNIP3 does not exhibit high expression but rather shows a downregulated trend, and this downregulation is associated with abnormal methylation mediated by DNA methyltransferase 3 (DNMT3) and DNA methyltransferase 1 (DNMT1) (134)