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Pregnancy and breastfeeding are also contraindicated due to a lack of safety data for systemic use in these populations

Brazil, 3rd edition, (2006)

In PTPSD, a tendency towards low birth weight has been observed [3]

Earlier Phase 2 monotherapy work also studied higher weekly doses up to 4.5 mg, but the cagrilintide-only schedule above matches the 2.4 mg weekly target shown throughout this page

In particular, this variant produces an altered fixation of SP1 and PC4 transcription factors in the promoter, resulting in a decreased transcription activity (Thanseem et al., 2010)