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Biol Trace Elem Res 160:169175 Ranasinghe P, Pigera S, Galappatthy P, Katulanda P, Constantine GR (2015) Zinc and diabetes mellitus: understanding molecular mechanisms and clinical implications

These NAD+ deficits contribute to metabolic dysfunction by impairing insulin sensitivity, reducing mitochondrial function, and promoting inflammatory responses that exacerbate metabolic pathology in research models