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Although not entirely equivalent to direct intra-articular irradiation, the clinical advancement of OFA technologya highly practicable form of intra-articular PBM that delivers light precisely to deep acupoints or periarticular tissuesprovides compelling evidence for this field

During oxidative stress, such as exposure to hydrogen peroxide, PARP-1 activation preserves hepatocyte survival, while PARP-1 inhibition or genetic ablation in primary hepatocytes diminishes oxidation-induced necrotic cell death, suggesting a preventive mechanism against oxidative injury (10)