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Side effects, when they occur, tend to be mild and dose related, such as injection site irritation or temporary water retention

Direct binding of eNOS to the scaffolding domain of Cav-1 is a well-accepted mechanism to repress eNOS activity that is associated with endothelial dysfunction and cardiovascular disease 39,40

The use of more efficient discretization methods, such as adaptive grids, and advanced optimization algorithms like quasi-Newton methods, can further reduce computation time, making the models more suitable for clinical applications

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