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Reagents and relative costs for different types of affinity chromatography

Peripheral administration and AAV-mediated liver expression of brain-penetrant PGRN biologics have been shown to rescue phenotypes of Grn / mice and Grn / Tmem106b / DKO mice, respectively [197, 210]

All the absorbance was read at 340 nm

The former mechanism is preferred because RS scavengers can be consumed during the reaction and may generate toxic radicals derived from the chelators ( One of the first chelating agents documented to reduce RS production (specifically the hydroxyl radical) in vitro was diethylenetriaminepentaacetic acid (DTPA)

Tumor-associated macrophages restrict CD8(+) T cell function through collagen deposition and metabolic reprogramming of the breast cancer microenvironment

Data availability Computer code for LSA, parameter estimation, numerical simulations, and GSA with PRCC was implemented in and run with the programming and computation software MATLAB (MathWorks Inc., Natick, MA, USA)