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About 1020% of patients are non-responders or modest responders

[1] Tirzepatide acts through two incretin receptors at once , GIP and GLP-1, adding a glucose-dependent insulin-secretion effect that an amylin analog does not have

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qRTPCR was performed via SYBR Premix Ex Taq II (Takara) on a Chromo 4 continuous fluorescence detector with a PTC-200 DNA Engine Cycler (Bio-Rad Laboratories, Hercules, CA)