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Lpez-Cantillo G, Uruea C, Camacho BA, Ramrez-Segura C

Data from MARCH/MARCH-ON, a clinical trial of maralixibat for individuals with PFIC, demonstrated reductions in sBA

The role of GST, GSTK, GSTO dimers, and GPX1 which function in glutathione conjugation, glucuronidation, methylation, and detoxification of reactive oxygen species, respectively, are detailed within Fig 3

10.1007/s11427-014-4714-2 147 LiX.KumarS.HarmanciA.LiS.KitchenR

cK1-1 and cK1-2 were folded into cK1-1f and cK1-2f, respectively, using the glutathione/glutathione disulfide redox system 46

The overall redox potential of a cell is primarily determined by oxidizable/reducible chemical pairs, including GSH/GSSH, reduced thioredoxin/oxidized thioredoxin, NAD+/NADH, and NADP+/NADPH, as shown in Fig