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Specifically, the centrifugation commonly used to separate cellular from plasmatic components for assay can produce not only force-induced mediator export that dominates the extracellular space, but also lysis of vulnerable RBCs

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For example, proton pump inhibitors (PPIs) and H2 receptor antagonists, commonly used to treat gastroesophageal reflux disease (GERD), can reduce the absorption of vitamin B12 and may necessitate adjustments in the dosing of methylcobalamin

Most interesting is the differential response to CB-839 across all three KP mouse models following the same treatment regimen

doi: 10.1016/j.phymed.2023.154703

120,125 Notably, Roberts et al