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Studies have indeed demonstrated that hyperhomocysteinemia compromises microvascular function in various organs, including the microvascular system within the kidneys [60]

Lin CY, Trinh NN, Fu SF, Hsiung YC, Chia LC, Lin CW, Huang HJ (2013) Comparison of early transcriptome responses to copper and cadmium in rice roots

Some nutritionists recommend increasing the intake of the amino acids cysteine and glutamate, which make glutathione, but this hasnt been studied either

Gastrointestinal side effects (nausea, vomiting, diarrhea, constipation) are common and dose-dependent

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The HPLC solvents were: solvent A, 1.5% v/v ortho-phosphoric acid (EMP Chemicals, Gibbstown, NJ), and solvent B, consisting of 80% acetonitrile (HPLC grade, Honeywell, Muskegon, MI) with 20% of solvent A