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This coupling reduces process modularity, as loading efficiency becomes sensitive to the metabolic state and relative expression kinetics of capsid proteins and engineered RNA, thereby increasing batch-to-batch variability relative to cell-free post-assembly methods (Segel et al., 2021

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The multi-factorial nature of clinical multidrug resistance in cancer

The reduced complex I activity in the SN is known as a considerable biochemical characteristic in Parkinsonian brain [72]