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Oxygen-glucose deprivation (OGD) or its combination with serum deprivation (OGSD) can significantly inhibit the viability, proliferation, migration, and multidifferentiation capacity of mesenchymal stem cells (MSCs), and induce oxidative stress and apoptosis (Turner et al., 2016

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The blood-brain barrier (BBB), formed by brain endothelial cells, regulates solute passage between blood and brain parenchyma, while the blood-cerebrospinal fluid barrier (BCSFB) at the choroid plexus controls exchange with cerebrospinal fluid