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The genes affected include negative regulators of cell cycle, such as PTEN, CDKN2C, CDKN1A, CDKN1C and p63 (35)

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Bi J et al (2022) Melatonin synergizes with methylprednisolone to ameliorate acute spinal cord injury

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However, the miR-21 expression by the influence of curcumin is downregulated in hepatocellular cancer cells, which stimulates the expression of metalloproteinase-3 (TIMP3) and suppresses the GF-b1/smad3 signalling, resulting in the proliferating of cancer cells (Li et al., 2020)

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Metabolic conditions People with diabetes or prediabetes can note that AOD 9604 does not impair glucose metabolism

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However, several other studies found higher thiamine levels in the brain after oral benfotiamine treatment in mice [20,21] and rats [22,63]

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