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An alteration in the metabolism of Met which results in HHcy is associated with risk for vascular disease as well as several other age-related pathologies

For example, the mitophagy inducer Urolithin A prevented ARHL in mice by enhancing the clearance of damaged mitochondria and improving mitochondrial DNA integrity and ATP production in the auditory system (Cho et al., 2024)

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This therapeutic resistance largely stems from GSHs strong antioxidant and detoxifying functions [17]

Peer review Peer review information Nature Communications thanks Rajesh Katare, Boyi Gan, Lu Cai and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

Sources NIH: Mitophagy Promotes Hair Regeneration by Activating Glutathione Metabolism NIH: Glutathione and its antiaging and antimelanogenic effects MedicalNewsToday: What are the benefits of glutathione