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Furthermore, interventional studies in DSS-colitis suggest targeting ferroptosis could be therapeutic: -caryophyllene inhibition of macrophage lipid peroxidation and ferroptosis was linked to suppression of inflammation [12], and seliciclib-treated micethat displayed reduced epithelial ferroptosishad less severe DSS-induced colitis [41]

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We validated the assays with known radioprotective drugs, including WR-1065, the active metabolite of Amifostine, the only FDA-approved preventative therapy for radiation-induced xerostomia 14,15,59

Werners syndrome is a type of condition, in which patients undergoing premature aging