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The outer mitochondrial membrane is relatively permeable, but the inner mitochondrial membrane is strictly impermeable to long-chain fatty acids

Accumulation of reactive fatty acids leads to mitochondria -oxidation imbalance that subsequently contributes to liver inflammatory injury and increased expression of proinflammatory cytokines interleukin-6 (IL-6), tumor necrosis factor- (TNF-), MCP-1, and IL-1, that further exacerbate SHBG depletion [52]

McGarry SV, Cruickshank D, Iloba I, Jensen GS

DB is the recipient of the Fondazione Umberto Veronesi fellowship

At least 33 strains can produce propionic acid and 225 strains can produce butyric acid by fermenting dietary fiber in human gut (Reichardt et al., 2014