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alkylation of a C3-amino-quinoline derived precursor, such as compound 8 may be achieved via reductive amination with, for example, triethyl orthoformate in TFA followed by treatment with NaBH 4 to give the corresponding secondary C3-amine derivative (such as N-methyl-C3-amino-quinoline 9)

Hitting it with a stream of water can create localized areas of very high concentration that do not dissolve evenly

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Genomic mutations associated with mild and severe deficiencies of transcobalamin I (haptocorrin) that cause mildly and severely low serum cobalamin levels

At the standard escalation of 2.5 mg for 4 weeks then 5 mg, you would use 10 mg in the first month (4 doses at 2.5 mg) and then continue at 5 mg per week

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