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Peripherally administered liraglutide is taken up by the hypothalamus (arcuate and paraventricular nuclei) where it stimulates pro-opiomelanocortin and amphetamine-regulated transcript to reduce appetite and induce weight loss

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Nat Neurosci 10:15441553 Leonardi A, Abbruzzese G, Arata L et al (1984) Cerebrospinal fluid (CSF) findings in amyotrophic lateral sclerosis