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B12 deficiency can cause mood changes, irritability, heightened anxiety, and depressive symptoms these are documented, clinically recognized consequences of insufficient B12

PMCID: PMC5112015

Adjunctive N-acetylcysteine in depression: exploration of interleukin-6, C-reactive protein and brain-derived neurotrophic factor

[10] Low NAD+ levels have recently been connected with a number of age-related disorders and illnesses that are linked to increased oxidative/free radical damage, including diabetes, heart disease, vascular dysfunction, ischemic brain injury, Alzheimers disease, and vision loss

The compound has been shown to restore decorin expression, which may help explain why GHK-Cu-treated skin often looks smoother even when collagen content changes are modest