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5-Amino-1-methylquinolinium iodide is the lead first-in-class small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT) an enzyme overexpressed in white adipose tissue of obese individuals where it consumes the methyl-donor pool and depletes tissue NAD

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In amounts normally used in cooking, it's otherwise safe

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Microbial metabolites such as butyrate, for instance, have shown to be potent regulators of zonulin and the intestinal barrier and appear to be essential mediators between microbial dysbiosis and barrier function