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5 Conclusions 1) This retrospective study provides the first in vivo evidence that DARA monotherapy, beyond its cytotoxic effects, modulates the secondary enzymatic functions of CD38 in MM, altering ADO and INO production and supporting a model of antibody-driven purinergic remodeling

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Although these studies report promising results regarding the sublingual route, it is important to note that almost all of them only include patients with mild, subclinical B12 deficiency, making it difficult to extrapolate their outcomes for patients with severe deficiency or malabsorptive states

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Vitamin B12 injections are a parenteral form of cobalamin (usually cyanocobalamin or hydroxocobalamin) given by intramuscular (IM) or subcutaneous (SC) injection