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In human colon cancer cells, silencing NNMT resulted in approximately a 30% increase in NAD + levels (Xie et al., 2014), whereas NNMT overexpression decreased NAD + levels by 30% (Xie et al., 2014)

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5Amino1MQ Peptide effectively improves hepatic lipid metabolism and reduces liver fat accumulation and inflammation by inhibiting NNMT