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Under unfolded protein stress conditions, GRP78 binds to unfolded or misfolded proteins and subsequently activates downstream ER stress sensors, including IRE1, PERK, and ATF6, to trigger a response to unfolded proteins (Yoboue et al., 2017) , (Wei et al., 2012)

Their study found multiple IDO2 gene mutations in ME/CFS patients, correlating with symptom severity

Zhu X, Cabungcal J-H, Cuenod M, Uliana DL, Do KQ, Grace AA

Apoptosis 28, 12851303

Finally, the blood samples were nitrated with nitric acid, and the ruthenium content was determined by ICP-MS