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In high L-arginine-dependent tumors, such as breast cancer (Abdelmagid et al., 2013), and HCC (Kishikawa et al., 2015), increased expression of the transporter CAT-1 ( SLC7A1 ) has been observed, and CAT-1 ( SLC7A1 ) knockdown decreases the viability of cancer cells and induces apoptosis

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An experimental study concluded that the Dusp6 gene is downregulated in stress affecting the transcriptional pathway in female mice, whereas ERK signaling and neuron excitability increased in males [106]