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10.1074/jbc.M115.698779 147 HarrazM

391 GLP-1 and GLP-1 analogs exert their effects on food intake and body weight through a myriad of neural substrates, encompassing several hypothalamic nuclei (including the arcuate nucleus of the hypothalamus, periventricular hypothalamus, and lateral hypothalamic area), hindbrain nuclei (such as the parabrachial nucleus and medial nucleus tractus solitarius), the ventral subregion of the hippocampus (vHP), and nuclei embedded within the mesolimbic reward circuitry (including the ventral tegmental area, VTA, and nucleus accumbens, NAc)

2.3 Amyotrophic lateral sclerosis (ALS) Recent human studies demonstrate that ALS patients have gut dysbiosis, defined primarily by decreased microbial diversity, such as lower populations of beneficial bacteria like Faecalibacterium , and increased levels of potentially harmful species like E

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Just one involved human subjects