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Multiple families and classes of GSTs exist in mammals, including soluble (alpha, mu, pi, theta, zeta, omega, sigma and kappa) and six-membered membranous (microsomal) named membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG), which all have a well-conserved G-(Glutathione-binding) site

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Vitamin B12 is necessary for two biological reactions