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Description

A systems chemoproteomic analysis of acyl-CoA/protein interaction networks

2023 Nov;43(11):1166-1181

PMC 3440559

L--glutamyl-p-nitroanilide (GPNA), an inhibitor of SLC1A5, has shown potential antitumoral effects through the inhibition of glutamine influx and by acting as a competitive inhibitor of SLC7A5 [also known as human L-type amino acid transporter 1 (LAT1)], inhibiting the influx of essential amino acids (70)

doi: 10.3389/fphar.2023.1217253 47 KauHCWuSBTsaiCCLiuCJWeiYH

Additionally, a bidirectional relationship between metabolic dysregulation and mitochondrial impairment in PCOS is suggested by the strong correlation between insulin resistance, hyperandrogenism, and mitochondrial dysfunction [37]