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Figure 3 illustrates the relationship between GSH concentration, peroxide concentration, and incubation time on the response variable

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Collectively, lactate acts as a metabolic checkpoint that can simultaneously suppress effector T cell functions while fostering immunosuppressive Tregs and, paradoxically, supporting the foundation of long-term immunity via memory CD8 T cells, highlighting a sophisticated and context-dependent immunomodulatory profile

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Koppe C, Verheugd P, Gautheron J, Reisinger F, Kreggenwinkel K, Roderburg C, et al

Notably, SHMT2 is a mitochondrial enzyme contributory to one-carbon metabolism by converting serine and tetrahydrofolate (THF) into glycine for GSH synthesis and a one-carbon unit, 5,10-methylenetetrahydrofolate (5,10-CH 2 -THF), for dTTP synthesis 35 , respectively