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The evidence regarding its impact on oxidative stress in migraine models remains limited, underscoring the need for careful consideration of dosages of topiramate and application conditions in the prophylactic treatment of migraines

Indeed, a decrease in the carnitine-dependent fatty acid transport system causes an accumulation of acyl-CoA molecules in the cytosol, and these metabolites inhibit the urea cycle ( Malaguarnera, 2013 )

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Clin Ther 38:12631271 Cotel F, Exley R, Cragg SJ, Perrier J-F (2013) Serotonin spillover onto the axon initial segment of motoneurons induces central fatigue by inhibiting action potential initiation

First, our findings are primarily applicable to populations of European ancestry