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Everyone is different, and what your body needs will be different from what works for someone else Your body can't store vitamin B12, so a vitamin B12 injection can be repeated once a week, and it's important to have repeat injections to ensure your body is functioning at its optimum level and receiving the vitamin B12 it needs to remain focused and healthy Some practitioners might recommend B-12 shots up to two times per week for energy and fat metabolism, or in combination with a MIC (Lipo) injection