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Eur Neurol 80:9399

Moreover, treadmill exercise (60 min/day, 5 days/week, 8 weeks) induces lactylation of endothelial methylated CpG-binding protein 2 (Mecp2) in murine models of atherosclerotic cardiovascular disease (ASCVD), which represses the Ereg/MAPK signaling pathway, thereby diminishing the expression of intercellular adhesion molecule 1, vascular cell adhesion molecule 1, monocyte chemoattractant protein 1, interleukin-1 (IL-1), interleukin-6 (IL-6), and increasing the level of eNOS in the aortic tissue [51]