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In contrast, in AD, iron dysregulation is more widespread across the cortex and hippocampus, where elevated iron levels are associated with faster cognitive decline

Without adequate glutathione in the brain, reactive nitrogen species, particularly peroxynitrite, accumulate rapidly

Mishra, A., Hogan, S

584,585 Clinical studies have demonstrated a correlation between iron levels in the substantia nigra and PD symptoms, including movement disorders

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