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Abstract INTRODUCTION SEARCH STRATEGY EXISTING RESCUE THERAPIES FOR ASUC CHALLENGES IN SELECTING THE RIGHT RESCUE THERAPY IN ASUC MECHANISMS OF INFLIXIMAB FAILURE MECHANISMS OF CYCLOSPORIN FAILURE IN ASUC SEQUENTIAL THERAPY MAINTENANCE THERAPY FOLLOWING SUCCESSFUL INDUCTION OF REMISSION IN ASUC WHEN TO CONSIDER COLECTOMY DISCUSSION CONCLUSIONS AND FUTURE DIRECTIONS NOTES REFERENCES Abstract Acute severe ulcerative colitis (ASUC) is a medical emergency that affects approximately 25% of patients with ulcerative colitis at some point in time in their lives