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pregnant patients at term (38 weeks to 42 weeks gestation), during labor and delivery, or when the onset of labor is imminent and in pediatric patients younger than 1 month of age because of the possibility of hemolytic anemia due to immature erythrocyte enzyme systems (glutathione instability) [see Warnings and Precautions (5.5) and Use in Specific Populations (8.1 and 8.4)]

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Moreover, vitamin C promotes keratinocyte differentiation and enhances the production of interstitial material, in order to maintain the normal function of the skin barrier (90)

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10.3390/genes13010142 34

It has been previously documented that increased oxidative stress regulates proteasome and immunoproteasome functions 43