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C b,L were used to estimate the fold difference (denoted as R kp ) between the right and left brain-to-plasma partition coefficients, K p,R and K p,L

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This suppression manifests as a 45% reduction in cyclic adenosine monophosphate (cAMP) levels and 53% inhibition of protein kinase A (PKA) activity, effectively disrupting the molecular machinery required for normal testicular function ( 3.2 Metabolic enzyme regulation and steroidogenesis EED interference with critical enzymatic pathways responsible for testosterone biosynthesis and xenobiotic detoxification creates profound hormonal imbalances that compromise reproductive function