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En 1877, dans le sang des malades, Georges Hayem dtecte les macrocytes ou globules rouges de grande taille, pauvres en hmoglobine

But whether these genes could be involved in how people respond differently to vaccines is not yet known

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(III.2.F) EXVIVO STUDY Ex vivo study on goat sublingual mucosa shows increase in permeation of drug through mucosa than that of In vitro condition because chitosan is able to break tight junction hence facilitate the passage of drug through this route .On the other hand PG will increase the pore size of the membrane along with alcohol as a result increase in Para-cellular movement of the drug .Therefore Ex- vivo data will help to predict In- vivo permeation pattern of the formulation